According to statistics, smokers are much more likely to suffer from chronic cardiovascular diseases than non-smokers

According to statistics, smokers are much more likely to suffer from chronic cardiovascular diseases than non-smokers. Explain the effects of toxic substances (such as carbon monoxide, nicotine) contained in tobacco smoke on blood red blood cells and blood vessels of a smoker?

1) There is a sharp narrowing of the blood vessels, the pressure rises
2) Reduces the elasticity of blood vessels, which can lead to a heart attack with increased pressure.
3) Harmful and toxic substances can be deposited on the walls of blood vessels.
4) Carbon monoxide interacts with hemoglobin of erythrocytes, as a result, their ability to carry oxygen decreases sharply, oxygen starvation of the whole organism occurs, and metabolism is impaired.