Heavy metal ions (mercury, arsenic, lead) easily react with sulfur to form sulfides. Explain what happens to protein

Heavy metal ions (mercury, arsenic, lead) easily react with sulfur to form sulfides. Explain what happens to protein when interacting with these metals. What are the links of the interaction?

Irreversible denaturation occurs under the influence of various chemicals (concentrated solutions of acids, alkalis, salts of heavy metals), high temperatures, and radiation. In this case, all protein structures are destroyed, the electric charges of its molecules are changed, which leads to their coalescence and coagulation. Disulfide bridges are destroyed (tertiary structure), there is an interaction with sulfur-containing amino acid fragments.

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