In humans, the recessive gene h, which causes one of the forms of hemophilia, is localized in the X chromosome and is inherited linked. This gene is semi-lethal for males and lethal for females.
1) Determine what is the probability of having a hemophilic son in healthy parents.
2) Healthy parents have three children, one of whom dies at the age of 14 from hemophilia. Determine how likely the other son and daughter are to be healthy.
1) a) If a woman is homozygous, then the probability of having a hemophilic son in healthy parents is 0; b) if a woman is heterozygous, then the probability of having a hemophilic son in healthy parents is 1/4;
2) the probability that the other son and daughter are healthy – 100% for the daughter and 50% for the son.
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