Phenylketonuria is a disease associated with a violation of amino acid metabolism, inherited in an autosomal dominant manner.

Phenylketonuria is a disease associated with a violation of amino acid metabolism, inherited in an autosomal dominant manner. The amino acid phenylalanine is not absorbed by the body and is converted to phenylpyruvic acid, which accumulates in the blood and is excreted in the urine. It has a toxic effect on the nerve cells of the brain and, as a result, develops a violation of higher nervous activity, dementia, a disorder of the regulation of motor functions. People homozygous for the recessive gene lack the ability to taste phenylthiourea. In northwestern Europe, the share of people who do not taste this substance is on average 37.5%. What is the frequency of phenylthiourea taste sensitivities?

The frequency of occurrence of persons sensitive to the taste of phenylthiourea is 62.5%.

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