What causes gene, chromosomal and genomic mutations in organisms. What factors are the causes of mutations?

Gene mutations are associated with changes in the structure of a gene (the structure of a DNA molecule). Violation of the structure of the gene can lead to: a) replacement, b) insertion, c) nucleotide loss,
Chromosomal mutations are associated with changes in the structure of chromosomes.
Genomic mutations are associated with a change in the number of chromosomes in the karyotype.

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