What effect do the substances that make up tobacco smoke have on the blood vessels and red blood cells of a smoker?

1) blood vessels narrow, disrupting blood supply;
2) some of the hemoglobin molecules combine with carbon monoxide, forming a strong connection, so hemoglobin is not able to transport oxygen and carbon dioxide;
3) in smokers, harmful substances from tobacco smoke are deposited on the walls of blood vessels, which increase the fragility of blood vessels, increase blood clotting, which leads to cardiovascular diseases.

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