Why can’t you get chickenpox a second time?

At the initial contact with the antigen, leukocytes and two types of lymphocytes enter into battle: T- and B-lymphocytes. T-lymphocytes directly detect and destroy the varicella-zoster virus and stimulate the synthesis of special B-lymphocytes – plasma cells that directly produce antibodies. In this case, part of the B-lymphocytes under the influence of this antigen turns into memory cells, which, upon repeated contact, provide a rapid immune response, i.e., acquired immunity. If the ability of T-lymphocytes to detect foreign antigens is blocked, the immune response becomes impossible, and the body is unarmed against infection. This is the mechanism of action of the human immunodeficiency virus, which is embedded in the T-lymphocyte membrane, causing the development of immunodeficiency.

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