Why Charles V, despite the enormous resources at his disposal, was unable to achieve his goals?

Charles V pursued a policy of centralization, but faced resistance from certain parts of his state, as well as from the nobility. The control system was cumbersome. The interaction between them was poorly established.

Remember: The process of learning a person lasts a lifetime. The value of the same knowledge for different people may be different, it is determined by their individual characteristics and needs. Therefore, knowledge is always needed at any age and position.