Why is a temperature above 40 ° C life threatening?

1) Many proteins in the cells act as catalysts – enzymes. Enzymes act only at a certain temperature (optimally 38 ° C) and pH of the medium. A prolonged increase in temperature above 38 ° C causes a change in the structure of the enzyme molecule (denaturation): its activity decreases and then stops. This leads to a violation of the entire metabolism.
2) The blood contains proteins that, at temperatures above 40 ° C, begin to denature, intravascular coagulation of the blood occurs.

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